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KMID : 0370019900040000050
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Chung-Ang Journal of Pharmacal Sciences
1990 Volume.4 No. 0 p.50 ~ p.59
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Effect of Aluminum Magnesium Hydroxide Suspension on Pharmacokinetics of Metronidazole in Rats
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Abstract
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The effect of aluminum-magnesium hydroxide suspension, antacid on the phamackinetics of metronidazole was investigated in female rats. Blood samples were collected at various time intervals for up to 24hr following the oral administration of metronidaz ole (50㎎ / ㎏) alone (clntrol group) or in combination of the antacid (1200㎎ / ㎏) administered concurrently (T_1 group), 1hr later (T_2 group) or 2hr later (T_3 group).
Plasma level-time curves were individually fitted to one-compartment open model with first order absorption. In group T_1 in which antacid was orally coadministered with metronidazole, the pharmacokinetic parameters of the drug were significantly in comparison with control studies, Group T_2, in which the dosing interval of antacid was 1hr sgowed that the pharmacokinetic parameters were not profoundly affected except profoundly decreased elimination rate constant and slightly decreased percent absorbed.
Group T_3, in which the dosing interval of antacid was 2hr, exhibited no significant changes when compared with control group. In view of the tendency of aluminum-magnesium hydroxide suspension observed in the present study todelay or reduce the absorption of metroridazole, the practitioner should aware of the potential disadvantage in combining with an antacid or concurrent dosing with an antacid. In order to minimize e the GI symptoms associated with metronidazole therapy, it is highly recommended that dosing interval of an antacid should be at least 2hr later following the oral administration of metronidazole.
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